The FDA wouldn't approve covid challenge trials a couple years ago. Healthy young people were eager to volunteer, and the need was dire. The case fatality rate was still high, and at that point we weren't expecting a vaccine for another couple years.
Yeah, in this case it'll be quite different. The WHO has guidelines to approve challenge trials, and I cite their expert discussion where they agree that challenge trials will be needed for Zika virus.
The parts about influenza and campylobacter challenge trials are new to me but that makes sense.
I was reading some of the literature on malaria challenge trials and that confirmed what you mentioned about the mosquito bite model, rather than using the sporozoites directly.
The FDA wouldn't approve covid challenge trials a couple years ago. Healthy young people were eager to volunteer, and the need was dire. The case fatality rate was still high, and at that point we weren't expecting a vaccine for another couple years.
Yeah, in this case it'll be quite different. The WHO has guidelines to approve challenge trials, and I cite their expert discussion where they agree that challenge trials will be needed for Zika virus.
All great points!
The parts about influenza and campylobacter challenge trials are new to me but that makes sense.
I was reading some of the literature on malaria challenge trials and that confirmed what you mentioned about the mosquito bite model, rather than using the sporozoites directly.
This is super informative; thank you!