Great post, particularly on the protective effect of the flu vaccine for cardiovascular outcomes, which I didn't know about.

But...given the p value of the large RCT (https://pubmed.ncbi.nlm.nih.gov/34459211/) is 0.04 and the upper limit of the confidence interval is a hair's breadth from the line of no effect, does this need further replication before taken as gospel?

I note this trial was in a population who weren't that elderly (mean age 60) but who did have a recent MI which presumably needs to be taken into consideration when extrapolating?

Would be interested to hear your thoughts!

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Jul 2, 2022Liked by Saloni Dattani

I wish someone would give you and Stuart like $10 million to found a new science magazine.

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How common is asymptomatic flu?

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